BDBM557694 US11358971, Compound 1c::US11466027, Compound 1e

SMILES Cc1ccnc2c1sc(c2)C(=O)NC[C@H](C(=O)O)N

InChI Key InChIKey=QRAZNSMFVGTRFM-UHFFFAOYSA-N

Data  3 KI  4 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 557694   

TargetGlutamate receptor ionotropic, NMDA 1/2B(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataEC50:  78nMAssay Description:Agonist activity at recombinant human GluN1/2B expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataKi:  96nMAssay Description:To determine the affinity of the compounds of the present invention a SPA is used. The assay is run in a 384-plate format (OptiPlate-384) where each ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataKi:  96nMAssay Description:Displacement of [3H]-MDL105519 from GluN1 LBD (unknown origin) incubated for 30 mins by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2C/3B(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataKi:  96nMAssay Description:To determine the affinity of the compounds of the present invention a SPA is used. The assay is run in a 384-plate format (OptiPlate-384) where each ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2C(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataEC50:  120nMAssay Description:Agonist activity at recombinant human GluN1/2C expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIonotropic glutamate receptor NMDA 1/2D(Rat)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataEC50:  450nMAssay Description:Agonist activity at recombinant human GluN1/2D expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
H. Lundbeck

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 557694BDBM557694(US11466027, Compound 1e | US11358971, Compound 1c)
Affinity DataEC50:  470nMAssay Description:Agonist activity at recombinant human GluN1/2A expressed in Xenopus laevis oocytes by TEVC recording methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)