BDBM558589 6-(2-chloro-3,5-dimethoxyphenyl)-N- (1,2,3,4-tetrahydroisoquinolin-6-yl)-[1, 2,4]triazolo[4',3':1,6]pyrido[2,3-d]pyri- midin-2-amine::US11365196, Compound 53

SMILES COc1cc(OC)c(Cl)c(c1)-c1cc2cnc(Nc3ccc4CNCCc4c3)nc2n2cnnc12

InChI Key InChIKey=UJKFLFOBPZHDJN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 558589   

TargetFibroblast growth factor receptor 1(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558589(6-(2-chloro-3,5-dimethoxyphenyl)-N- (1,2,3,4-tetra...)
Affinity DataIC50: 0.600nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558589(6-(2-chloro-3,5-dimethoxyphenyl)-N- (1,2,3,4-tetra...)
Affinity DataIC50: 1.5nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM558589(6-(2-chloro-3,5-dimethoxyphenyl)-N- (1,2,3,4-tetra...)
Affinity DataIC50: 14nMAssay Description:The inhibitory activity of some compounds of the present disclosure against FGFR1, FGFR2, FGFR3, FGFR4, KDR was tested by mobility shift assay (conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent