BDBM559477 BDBM50564375::US11370779, Compound 45

SMILES CN1CCN(CCO\N=C2\C(\Nc3ccccc\23)=C2\C(=O)Nc3ccc(OC(F)(F)F)cc23)CC1

InChI Key InChIKey=OCLVHVBLQIOWFP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 559477   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM559477(US11370779, Compound 45 | BDBM50564375)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of recombinant His-tagged human FLT3 expressed in baculovirus expression system using peptide substrate incubated for 30 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Gwangju Institute of Science and Technology

Curated by ChEMBL
LigandPNGBDBM559477(US11370779, Compound 45 | BDBM50564375)
Affinity DataIC50: 5.60nMAssay Description:The inhibition of the FLT3 kinase activity was measured with homogeneous, time-resolved fluorescence (HTRF) assays. Recombinant proteins containing t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
Go to US Patent