BDBM559882 N-[3-[2-(3-hydroxy-3-methylbut-1-yn-1- yl)-6-(morpholin-4-yl)pyridin-4-yl]-4- methylphenyl]-2- (trifluoromethyl)pyridine-4-carboxamide::US11377431, Example 3

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cc(nc(c1)N1CCOCC1)C#CC(C)(C)O

InChI Key InChIKey=YQQYJWLLOVPVSE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 559882   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM559882(US11377431, Example 3 | N-[3-[2-(3-hydroxy-3-methy...)
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of the BRA and RAF kinases was measured using ADP-Glo assay. In the assay, ADP is converted to ATP in the presence of test ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
US Patent