BDBM561108 1-(6-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)pyrimidin- 2-yl)-1H-indole-2- carbonyl)pyrrolidine-3- carbonitrile::US11390609, Compound TDI01448

SMILES O=C(N1CCC(C1)C#N)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1

InChI Key InChIKey=MEBNSBJAXOQIQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561108   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561108(1-(6-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)pyrimid...)
Affinity DataIC50: 13nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561108(1-(6-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)pyrimid...)
Affinity DataIC50: 3.00E+3nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent