BDBM561112 6-(4-((4-(1H-pyrazol-4- yl)phenyl)amino)pyrimidin- 2-yl)-1-methyl-N- (1,1,1-trifluoropropan-2- yl)-1H-indole-2-carboxamide::US11390609, Compound TDI01457::US11390609, Compound TDI01691

SMILES CC(NC(=O)c1cc2ccc(cc2n1C)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1)C(F)(F)F

InChI Key InChIKey=OKFVYXIAPUEGJG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 561112   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561112(US11390609, Compound TDI01457 | US11390609, Compou...)
Affinity DataIC50: 6nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561112(US11390609, Compound TDI01457 | US11390609, Compou...)
Affinity DataIC50: 159nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561112(US11390609, Compound TDI01457 | US11390609, Compou...)
Affinity DataIC50: 395nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561112(US11390609, Compound TDI01457 | US11390609, Compou...)
Affinity DataIC50: 4.89E+3nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent