BDBM561138 (6-(4-((4-(1H-pyrazol-4-yl) phenyl)amino)pyrimidin-2yl)- 1-methyl-1H-indol-2-yl)(6,6- difluoro-3-azabicyclo[3.1.0] hexan-3-yl)methanone::US11390609, Compound TDI01512

SMILES Cn1c(cc2ccc(cc12)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1)C(=O)N1CC2C(C1)C2(F)F

InChI Key InChIKey=PRNMPKIYDQYQLX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561138   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561138((6-(4-((4-(1H-pyrazol-4-yl) phenyl)amino)pyrimidin...)
Affinity DataIC50: 22nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561138((6-(4-((4-(1H-pyrazol-4-yl) phenyl)amino)pyrimidin...)
Affinity DataIC50: 3.63E+3nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent