BDBM561157 (3,3- difluorocyclobutyl)(5- (4-((2-methoxy-4-(1H- pyrazol-4-yl)phenyl) amino)pyrimidin-2-yl) isoindolin-2- yl)methanone::US11390609, Compound TDI01550

SMILES COc1cc(ccc1Nc1ccnc(n1)-c1ccc2CN(Cc2c1)C(=O)C1CC(F)(F)C1)-c1cn[nH]c1

InChI Key InChIKey=QKRVKZCCWAUBLF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561157   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561157((3,3- difluorocyclobutyl)(5- (4-((2-methoxy-4-(1H-...)
Affinity DataIC50: 21nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561157((3,3- difluorocyclobutyl)(5- (4-((2-methoxy-4-(1H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent