BDBM561174 3,3- difluorocyclobutyl 5-(4-((1H-indazol-5- yl)amino)pyrimidin- 2-yl)isoindoline-2- carboxylate::US11390609, Compound TDI01580

SMILES FC1(F)CC(C1)OC(=O)N1Cc2ccc(cc2C1)-c1nccc(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=GTZLKFYOUNSLGV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561174   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561174(3,3- difluorocyclobutyl 5-(4-((1H-indazol-5- yl)am...)
Affinity DataIC50: 19nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561174(3,3- difluorocyclobutyl 5-(4-((1H-indazol-5- yl)am...)
Affinity DataIC50: 3.29E+3nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent