BDBM561188 3,3- difluorocyclobutyl 5-(4-((1H-indazol-5- yl)amino)-5- fluoropyrimidin-2- yl)isoindoline-2- carboxylate::US11390609, Compound TDI01613

SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)-c1ccc2CN(Cc2c1)C(=O)OC1CC(F)(F)C1

InChI Key InChIKey=WKFDIJXBQKTJGY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561188   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561188(3,3- difluorocyclobutyl 5-(4-((1H-indazol-5- yl)am...)
Affinity DataIC50: 27nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561188(3,3- difluorocyclobutyl 5-(4-((1H-indazol-5- yl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent