BDBM561196 2- azaspiro[3.3]heptan 6-yl 5-(4-((4-(1H- pyrazol-4- yl)phenyl)amino) pyrimidin-2- yl)isoindoline-2- carboxylate::US11390609, Compound TDI01634

SMILES O=C(OC1CC2(CNC2)C1)N1Cc2ccc(cc2C1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1

InChI Key InChIKey=XKSJHYCLFDOAEV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561196   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561196(2- azaspiro[3.3]heptan 6-yl 5-(4-((4-(1H- pyrazol-...)
Affinity DataIC50: 16nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561196(2- azaspiro[3.3]heptan 6-yl 5-(4-((4-(1H- pyrazol-...)
Affinity DataIC50: 2.04E+3nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent