BDBM561230 (6-(4-((4-(1H- pyrazol-4- yl)phenyl)amino)- 6,7-dihydro- [1,4]dioxino[2,3- d]pyrimidin-2- yl)-1-methyl-1H- indol-2-yl)(3,3- difluoroazetidin- 1-yl)methanone::US11390609, Compound TDI01851

SMILES Cn1c(cc2ccc(cc12)-c1nc(Nc2ccc(cc2)-c2cn[nH]c2)c2OCCOc2n1)C(=O)N1CC(F)(F)C1

InChI Key InChIKey=COYWOVSINRILEP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561230   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561230((6-(4-((4-(1H- pyrazol-4- yl)phenyl)amino)- 6,7-di...)
Affinity DataIC50: 15nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561230((6-(4-((4-(1H- pyrazol-4- yl)phenyl)amino)- 6,7-di...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent