BDBM561294 (5-(4-((4-(1H-pyrazol- 4-yl)phenyl)amino)-6,7- dihydro-5H-pyrrolo [3,4-d]pyrimidin-2- yl)isoindolin-2-yl)(3,3- difluorocyclobutyl) methanone::US11390609, Compound TDI01999

SMILES FC1(F)CC(C1)C(=O)N1Cc2ccc(cc2C1)-c1nc2CNCc2c(Nc2ccc(cc2)-c2cn[nH]c2)n1

InChI Key InChIKey=MRJQCGZKRXTOBU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 561294   

TargetRho-associated protein kinase 2(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561294((5-(4-((4-(1H-pyrazol- 4-yl)phenyl)amino)-6,7- dih...)
Affinity DataIC50: 10nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Beijing Tide Pharmaceutical

US Patent
LigandPNGBDBM561294((5-(4-((4-(1H-pyrazol- 4-yl)phenyl)amino)-6,7- dih...)
Affinity DataIC50: 1.00E+4nMAssay Description:The kinase IC50 was determined by a commercialized CISBIO kinase detection kit, HTRF KinEASE-STK S2 kit (62ST2PEC). ROCK2 (01-119) employed in the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent