BDBM563389 5-(2,4-difluoro phenyl)-N-(4-((4- methylpiperazin-1-yl) methyl)phenyl)-4- ((tetrahydrofuran-2- yl)methoxy)-7H- pyrrolo[2,3-d] pyrimidin-2-amine::US11407757, Cpd 52

SMILES CN1CCN(Cc2ccc(Nc3nc(OCC4CCCO4)c4c(c[nH]c4n3)-c3ccc(F)cc3F)cc2)CC1

InChI Key InChIKey=GUPVHOUYUOOHMG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 563389   

TargetTyrosine-protein kinase receptor UFO(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM563389(US11407757, Cpd 52 | 5-(2,4-difluoro phenyl)-N-(4-...)
Affinity DataIC50: 30nMAssay Description:Certain compounds of formula (I) were tested for their potency in inhibiting Axl kinase. Inhibition of Axl kinase activity by a test compound was cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
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TargetTyrosine-protein kinase Mer(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM563389(US11407757, Cpd 52 | 5-(2,4-difluoro phenyl)-N-(4-...)
Affinity DataIC50: 250nMAssay Description:Certain compounds of formula (I) were tested for their potency in inhibiting Mer kinase. Inhibition of Mer kinase activity by a test compound was cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM563389(US11407757, Cpd 52 | 5-(2,4-difluoro phenyl)-N-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Certain compounds of formula (I) were tested for their potency in inhibiting Met kinase. Inhibition of Met kinase activity by a test compound was cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent