BDBM563391 5-(2,4-difluoro phenyl)-N4-ethyl-N2- (4-((4-methyl piperazin-1-yl) methyl)phenyl)-7H- pyrrolo[2,3-d] pyrimidine-2,4- diamine::US11407757, Cpd 54

SMILES CCNc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)nc2[nH]cc(-c3ccc(F)cc3F)c12

InChI Key InChIKey=WAHPBOBQSDMVRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 563391   

TargetTyrosine-protein kinase receptor UFO(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM563391(US11407757, Cpd 54 | 5-(2,4-difluoro phenyl)-N4-et...)
Affinity DataIC50: 30nMAssay Description:Certain compounds of formula (I) were tested for their potency in inhibiting Axl kinase. Inhibition of Axl kinase activity by a test compound was cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
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TargetTyrosine-protein kinase Mer(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM563391(US11407757, Cpd 54 | 5-(2,4-difluoro phenyl)-N4-et...)
Affinity DataIC50: 65nMAssay Description:Certain compounds of formula (I) were tested for their potency in inhibiting Mer kinase. Inhibition of Mer kinase activity by a test compound was cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Development Center For Biotechnology

US Patent
LigandPNGBDBM563391(US11407757, Cpd 54 | 5-(2,4-difluoro phenyl)-N4-et...)
Affinity DataIC50: 700nMAssay Description:Certain compounds of formula (I) were tested for their potency in inhibiting Met kinase. Inhibition of Met kinase activity by a test compound was cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent