BDBM563564 US11419874, Example 5

SMILES CCCCOc4ccc(F)c(c2nc(C)c3nnc1ccc(OC)nc1n23)c4

InChI Key InChIKey=JISGWKBRIFXTKG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 563564   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM563564(US11419874, Example 5)
Affinity DataIC50: 4.12nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM563564(US11419874, Example 5)
Affinity DataIC50: 500nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM563564(US11419874, Example 5)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human recombinant PDE2A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Oslo University Hospital

US Patent
LigandPNGBDBM563564(US11419874, Example 5)
Affinity DataIC50: 670nMAssay Description:Inhibition of human recombinant PDE10A using [3H]-cAMP as substrate incubated for 30 mins by radiometric based liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed