BDBM563615 Cyclobutanecarboxylic acid [4-(2- {2-[3-(5-tert-butyl-2-p-tolyl-2H- pyrazol-3-yl)-ureido]-thiazol-5- yl}-ethyl)-pyridin-2-yl]-amide::US11407771, Compound 332

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ncc(CCc2ccnc(NC(=O)C3CCC3)c2)s1)C(C)(C)C

InChI Key InChIKey=LOLMAOSDOITSIX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 563615   

TargetMitogen-activated protein kinase 13(Human)
Washington University

US Patent
LigandPNGBDBM563615(US11407771, Compound 332 | Cyclobutanecarboxylic a...)
Affinity DataIC50: 18nMAssay Description:ach of these analogs were checked for physical chemical characteristics based on molecular weight, Lipinski's Rule of 5, partition coefficient (l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Washington University

US Patent
LigandPNGBDBM563615(US11407771, Compound 332 | Cyclobutanecarboxylic a...)
Affinity DataIC50: 193nMAssay Description:ach of these analogs were checked for physical chemical characteristics based on molecular weight, Lipinski's Rule of 5, partition coefficient (l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Washington University

US Patent
LigandPNGBDBM563615(US11407771, Compound 332 | Cyclobutanecarboxylic a...)
Affinity DataIC50: 193nMAssay Description:ach of these analogs were checked for physical chemical characteristics based on molecular weight, Lipinski's Rule of 5, partition coefficient (l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase 13(Human)
Washington University

US Patent
LigandPNGBDBM563615(US11407771, Compound 332 | Cyclobutanecarboxylic a...)
Affinity DataIC50: 250nMAssay Description:ach of these analogs were checked for physical chemical characteristics based on molecular weight, Lipinski's Rule of 5, partition coefficient (l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent