BDBM5671 2-amino-substituted thiazole 51::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methane]sulfinyl}-1,3-thiazol-2-yl)-2-methylpropanamide::N-[5-[[(5-tert-Butyl-2-oxazolyl)methyl]sulfinyl]-2-thiazolyl]-2-isopropylamide

SMILES CC(C)C(=O)Nc1ncc(s1)S(=O)Cc1ncc(o1)C(C)(C)C

InChI Key InChIKey=GTTXLAIKLNNNQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5671   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5671(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methane]sulfi...)
Affinity DataIC50: 140nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5671(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methane]sulfi...)
Affinity DataIC50: 140nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5671(N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methane]sulfi...)
Affinity DataIC50: 2.50E+4nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2005
Entry Details Article
PubMed