BDBM567676 US11420968, Example F42::US11420970, Example 1

SMILES COc1ccc(cc1F)-c1cc(Cn2cnc3c(N)ncnc23)c(cn1)N1CCC[C@@H](N)C1

InChI Key InChIKey=ZLEUKUNFAVEEND-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 567676   

TargetHistone-lysine N-methyltransferase NSD2(Human)
Novartis

US Patent
LigandPNGBDBM567676(US11420970, Example 1 | US11420968, Example F42)
Affinity DataIC50: 525nMAssay Description:This assay employed LC-MS/MS technology to monitor the SAH production from the NSD2 enzymatic reaction. The enzymatic reaction was performed in white...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567676(US11420970, Example 1 | US11420968, Example F42)
Affinity DataIC50: 44nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567676(US11420970, Example 1 | US11420968, Example F42)
Affinity DataIC50: 0.0150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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TargetBcl-2-like protein 1(Human)
Beigene

US Patent
LigandPNGBDBM567676(US11420970, Example 1 | US11420968, Example F42)
Affinity DataIC50: 18nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent