BDBM567679 US11420968, Example F45

SMILES CC(C)c1ccccc1[C@@H]1CCCN1C1CC2(C1)CCN(CC2)c1ccc(C(=O)NS(=O)(=O)c2ccc(NCC3CCOCC3)c(c2)[N+]([O-])=O)c(Oc2cnc3[nH]ccc3c2)c1

InChI Key InChIKey=CLRIOMZLSLAWHG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 567679   

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567679(US11420968, Example F45)
Affinity DataIC50: 0.0360nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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TargetBcl-2-like protein 1(Human)
Beigene

US Patent
LigandPNGBDBM567679(US11420968, Example F45)
Affinity DataIC50: 46nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567679(US11420968, Example F45)
Affinity DataIC50: 0.0360nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
Beigene

US Patent
LigandPNGBDBM567679(US11420968, Example F45)
Affinity DataIC50: 46nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

TargetCytochrome P450 2C9(Human)
Beigene

US Patent
LigandPNGBDBM567679(US11420968, Example F45)
Affinity DataIC50: 8.90E+3nMAssay Description:The five isoform-selective probe substrate (in a cocktail manner) was used as a measure of activity for the individual cytochrome P450 (CYPs) in a po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent