BDBM567800 US11420968, Example F43

SMILES CC(C)c1ccccc1[C@@H]2CCCN2C3CC4(C3)CCN(CC4)c5ccc(c(c5)Oc6cc7cc[nH]c7nc6)C(=O)NS(=O)(=O)c8ccc(c(c8)N(=O)=O)NCC9CCC(CC9)(C)O

InChI Key InChIKey=ZQTKOYMWCCSKON-UHFFFAOYSA-N

Data  4 IC50

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 567800   

TargetApoptosis regulator Bcl-2 [G101V](Human)
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50: 0.420nMAssay Description:Selected compounds disclosed herein were tested for blocking of Bcl-2-G101 protein with its ligand in an assay based on time-resolved fluorescence re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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TargetApoptosis regulator Bcl-2(Human)
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50: 0.0150nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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TargetBcl-2-like protein 1(Human)
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50: 18nMAssay Description:Compounds disclosed herein were tested for blocking of Bcl-2/Bcl-X protein with its ligand in an assay based on Time-Resolved Fluorescence Resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
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TargetCytochrome P450 2C9(Human)
Beigene

US Patent
LigandPNGBDBM567800(US11420968, Example F43)
Affinity DataIC50: 3.00E+4nMAssay Description:The five isoform-selective probe substrate (in a cocktail manner) was used as a measure of activity for the individual cytochrome P450 (CYPs) in a po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent