BDBM568509 (R)-(3-Aminopiperidin-1-yl)(3-cyclopropyl-2-(1-(cyclopropylmethyl)-1H-indol-2-yl)imidazo[1,2-a]pyridin-7-yl)methanone::US11426412, Compound 33

SMILES N[C@@H]1CCCN(C1)C(=O)c1ccn2c(C3CC3)c(nc2c1)-c1cc2ccccc2n1CC1CC1

InChI Key InChIKey=SVCMOYNMNMJQEZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 568509   

TargetProtein-arginine deiminase type-4(Human)
Jubilant Epipad

US Patent
LigandPNGBDBM568509((R)-(3-Aminopiperidin-1-yl)(3-cyclopropyl-2-(1-(cy...)
Affinity DataIC50: 5.50E+3nMAssay Description:Citrullination assay was detected via ammonia release. PAD4 was diluted to 120 nM in assay buffer (100 mM HEPES, 50 mM NaCl, 2 mM DDT, 0.6 mg/mL BSA,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
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TargetProtein-arginine deiminase type-4(Human)
Jubilant Epipad

US Patent
LigandPNGBDBM568509((R)-(3-Aminopiperidin-1-yl)(3-cyclopropyl-2-(1-(cy...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding of compounds with PAD4 was detected by FP assay. PAD4 was diluted to 1 uM in assay buffer (100 mM HEPES, 50 mM NaCl, 1 mM DTT, 5% Glycerol an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
Go to US Patent