BDBM570914 US11440904, Compound 12

SMILES CCC(=O)Nc1ccccc1Nc1nc(Nc2ccc3OCCOCCOCCOc3c2)nc2[nH]cnc12

InChI Key InChIKey=MQSCGRDOQBVIMP-UHFFFAOYSA-N

Data  17 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 570914   

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 2.70nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

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Date in BDB:
11/19/2022
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TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 2.70nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 4.36nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 4.36nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 4.36nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 14.1nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 14.1nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase BTK [C481S](Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 14.1nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 24.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 24.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetFocal adhesion kinase 1(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 24.6nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase ITK/TSK(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 447nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetTyrosine-protein kinase ITK/TSK(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 447nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMitogen-activated protein kinase 3(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 714nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
Copy BDB DOIUS Patent

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TargetEpidermal growth factor receptor(Human)
Milstein Zhang & Wu

US Patent

LigandBDBM570914(US11440904, Compound 12)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/19/2022
Entry Details
Copy BDB DOIUS Patent

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