BDBM572228 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-11,12,13,14-tetrahydro-2H,10H-pyrazolo[3′,4′:2,3][1,6]oxazacycloundecino[4,5,6-hi]indole-8-carboxylic Acid::US11447504, Example 83::US11447504, Example 84::US11447504, Example 85

SMILES Cc1c-2c(OCCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C

InChI Key InChIKey=OMYQPDVOHAOLPZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 572228   

LigandPNGBDBM572228(US11447504, Example 85 | US11447504, Example 84 | ...)
Affinity DataIC50: 1.90nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent

LigandPNGBDBM572228(US11447504, Example 85 | US11447504, Example 84 | ...)
Affinity DataIC50: 4.5nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent

LigandPNGBDBM572228(US11447504, Example 85 | US11447504, Example 84 | ...)
Affinity DataIC50: 53nMAssay Description:The dose-dependent inhibition by the compounds described in this invention of the interaction between MCL-1 and the BH3 domain of Noxa (both human) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2022
Entry Details
US Patent