BDBM575665 US11464802, Compound 28

SMILES CCOc1cc(cc(n1)N1Cc2c(cc(CN3CCC(F)(F)[C@H](C)C3)cc2C(F)(F)F)C1=O)C1(Cc2nncn2C)COC1

InChI Key InChIKey=WIBSWIYCGWVBDZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 575665   

LigandPNGBDBM575665(US11464802, Compound 28 | US20250230147, Compound ...)
Affinity DataIC50: 3nMAssay Description:Fluorescently-labeled inhibitor probe was synthesized and tagged with BODIPY FL (Example 46). Cbl-b displacement assays were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandPNGBDBM575665(US11464802, Compound 28 | US20250230147, Compound ...)
Affinity DataIC50: 14nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandPNGBDBM575665(US11464802, Compound 28 | US20250230147, Compound ...)
Affinity DataIC50: 22nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent