BDBM576415 (R)-2-(1-Cyclopropyl-2-hydroxy-2-methylpropyl)-7-(4-(5-methyl-1,3,4-oxadiazol-2- yl)phenyl)isoindolin-1-one::WO2022115301, Example 1

SMILES Cc1nnc(o1)-c1ccc(cc1)-c1cccc2CN([C@H](C3CC3)C(C)(C)O)C(=O)c12

InChI Key InChIKey=OCGPMALGLNABTO-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 576415   

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576415(WO2022115301, Example 1 | (R)-2-(1-Cyclopropyl-2-h...)
Affinity DataEC50:  7.90nMAssay Description: Using Promega s UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2022
Entry Details
WIPO WO2022115301

TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576415(WO2022115301, Example 1 | (R)-2-(1-Cyclopropyl-2-h...)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of GCS in human A-375 cell golgi body preparations using ceramide and UDP-glucose as substrate by UDP-Glo based luminometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetCeramide glucosyltransferase(Human)
Merck Sharp &Amp

WIPO
LigandPNGBDBM576415(WO2022115301, Example 1 | (R)-2-(1-Cyclopropyl-2-h...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of GCS in wild type HDF cells by LC-MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed