BDBM579887 (S)-N-((S)- 3-(3,4- dihydro- isoquinolin- 2(1H)- yl)-2- hydroxy- propyl)-::US11485731, Example 1AN::US11485731, Example 5A::US11485731, Example 5B

SMILES O[C@@H](CNC(=O)N1CCC[C@H](C1)c1ccccc1)CN1CCc2ccccc2C1

InChI Key InChIKey=UNJFWYGMXNSASF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 579887   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM579887(US11485731, Example 1AN | (S)-N-((S)- 3-(3,4- dihy...)
Affinity DataIC50: 14nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM579887(US11485731, Example 1AN | (S)-N-((S)- 3-(3,4- dihy...)
Affinity DataIC50: 26nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Argonaut Therapeutics

US Patent
LigandPNGBDBM579887(US11485731, Example 1AN | (S)-N-((S)- 3-(3,4- dihy...)
Affinity DataIC50: 599nMAssay Description:A PRMT5 chemiluminescent assay was used to measure the IC50 activity of PRMT5 of the compounds of Examples 1A to 7 above. Biotinylated histone peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
US Patent