BDBM581370 US11505527, Compound 4b

SMILES CCOC(=O)C1=C(NC2=C(C1c1ccc(cc1)S(=O)(=O)c1ccccc1)C(=O)CC(C)(C)C2)C(F)(F)F

InChI Key InChIKey=JPJAUHSLJCUGAH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 581370   

TargetEpidermal growth factor receptor(Human)
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50: 0.220nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50: 0.600nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50: 0.420nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
King Abdulaziz University

US Patent
LigandPNGBDBM581370(US11505527, Compound 4b)
Affinity DataIC50: 2.10nMAssay Description:An in vitro kinase assay was performed to evaluate the kinase suppression activity of the most promising cytotoxic candidates 4b, 4j against four dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
Go to US Patent