BDBM581490 (R)-2-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-3- fluoro-6-(o-tolyl)-8-(1,1,1-trifluoropropan-2-yl)-1,6-naphthyridin-5(6H)-one::US11505536, Example 38

SMILES CCn1c(CO)nn(-c2nc3c(cn(-c4ccccc4C)c(=O)c3cc2F)[C@@H](C)C(F)(F)F)c1=O

InChI Key InChIKey=DXXAVWVZVVNCDI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 581490   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581490(US11505536, Example 38 | (R)-2-(4-Ethyl-3-(hydroxy...)
Affinity DataIC50: 0.464nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent