BDBM581498 6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7-fluoro- 4-(prop-1-en-2-yl)-2-(o-tolyl)isoquinolin-1(2H)-one::US11505536, Example 46

SMILES CCn1c(CO)nn(-c2cc3c(cn(-c4ccccc4C)c(=O)c3cc2F)C(C)=C)c1=O

InChI Key InChIKey=BAVSNPFZUNHXMW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 581498   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581498(US11505536, Example 46 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.746nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
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Date in BDB:
1/21/2023
Entry Details
US Patent