BDBM581506 2-(2-Chloro-6-fluorophenyl)-6-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro- 1H-1,2,4-triazol-1-yl)-7-fluoro-4-isopropylphthalazin-1(2H)-one::US11505536, Example 54

SMILES CCn1c(CO)nn(-c2cc3c(nn(-c4c(F)cccc4Cl)c(=O)c3cc2F)C(C)C)c1=O

InChI Key InChIKey=KYMZNGCYFSMKSP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 581506   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581506(US11505536, Example 54 | 2-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 0.433nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
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Date in BDB:
1/21/2023
Entry Details
US Patent