BDBM581509 (R*)-6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7- fluoro-2-(o-tolyl)-4-(1,1,1-trifluoropropan-2-yl)phthalazin-1(2H)-one::US11505536, Example 57

SMILES CCN1C(=NN(C1=O)c2cc3c(cc2F)C(=O)N(N=C3[C@@H](C)C(F)(F)F)c4ccccc4C)CO

InChI Key InChIKey=ATPQLRLIRAXHDW-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 581509   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Biotech

US Patent
LigandPNGBDBM581509(US11505536, Example 57 | (R*)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 1.15nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)