BDBM582097 US11518764, Compound I-12::US11518764, Compound I-190::US11518764, Compound I-252::acsmedchemlett.2c00502 OICR 10646D, 33

SMILES Cn1cnc2n(CC(=O)Nc3cc(ncc3Cl)N3CCOCC3)cc(-c3cc(Cl)c(O)c(c3)C(N)=O)c2c1=O

InChI Key InChIKey=LYPIBXVPZCTMSW-UHFFFAOYSA-N

Data  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 582097   

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582097(US11518764, Compound I-190 | US11518764, Compound ...)
Affinity DataKd:  10nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM582097(US11518764, Compound I-190 | US11518764, Compound ...)
Affinity DataKd:  10nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582097(US11518764, Compound I-190 | US11518764, Compound ...)
Affinity DataKd:  13nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM582097(US11518764, Compound I-190 | US11518764, Compound ...)
Affinity DataKd:  16.2nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM582097(US11518764, Compound I-190 | US11518764, Compound ...)
Affinity DataKd:  26.5nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent