BDBM582231 US11518764, Compound I-240::US11518764, Compound I-313::acsmedchemlett.2c00502 OICR 11090D, 35

SMILES C[C@H]1CN(C)CCN1c1cc(NC(=O)Cn2cc(-c3cc(Cl)c(O)c(c3)C(N)=O)c3c2ncn(C)c3=O)c(Cl)cn1

InChI Key InChIKey=FRJRUCNOMGJHID-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 582231   

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582231(US11518764, Compound I-313 | US11518764, Compound ...)
Affinity DataKd:  11nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582231(US11518764, Compound I-313 | US11518764, Compound ...)
Affinity DataKd:  11nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM582231(US11518764, Compound I-313 | US11518764, Compound ...)
Affinity DataKd:  14.2nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM582231(US11518764, Compound I-313 | US11518764, Compound ...)
Affinity DataKd:  27.8nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent