BDBM582399 US11518764, Compound I-412::acsmedchemlett.2c00502 OICR 12723D, 47

SMILES COc1c(O)c(cc(-c2cn(CC(=O)Nc3cc(nc(F)c3Cl)N3CCN(C)C[C@@H]3C)c3ncn(C)c(=O)c23)c1F)C(N)=O

InChI Key InChIKey=XGWSFJCKZRJJKS-UHFFFAOYSA-N

Data  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 582399   

TargetB-cell lymphoma 6 protein(Human)
Ontario Institute For Cancer Research (Oicr)

US Patent
LigandPNGBDBM582399(US11518764, Compound I-412 | acsmedchemlett.2c0050...)
Affinity DataKd:  42.7nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582399(US11518764, Compound I-412 | acsmedchemlett.2c0050...)
Affinity DataKd:  43nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582399(US11518764, Compound I-412 | acsmedchemlett.2c0050...)
Affinity DataKd:  43nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed