BDBM585263 US11530197, Compound 191

SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)c2c[nH]c(n2)-c2c(ncn2CC(F)(F)F)-c2ccc(F)cc2)cc1

InChI Key InChIKey=KKTSTGVVZJAZJX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 585263   

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM585263(US11530197, Compound 191)
Affinity DataIC50: 66nMAssay Description:TNIK(h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM RLGRDKYKTLRQIRQ, 10 mM Magnesium Acetate and [gamma-33P-ATP](specific activity a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM585263(US11530197, Compound 191)
Affinity DataIC50: 66nMAssay Description:MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM RLGRDKYKTLRQIRQ, 10 mM Magnesium Acetate and [gamma-33P-ATP](specific activit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM585263(US11530197, Compound 191)
Affinity DataIC50: 66nMAssay Description:The required volume of the 50× stock of test compound was added to the assay before a reaction mix containing the enzyme and substrate was added. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM585263(US11530197, Compound 191)
Affinity DataIC50: 66nMAssay Description:The required volume of the 50× stock of test compound was added to the assay before a reaction mix containing the enzyme and substrate was added. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent