BDBM585344 5-(4-(quinolin-3-yl)piperazin- 1-yl)pyrimidine-2,4-diamine::US11530198, Example 19

SMILES Nc1ncc(N2CCN(CC2)c2cnc3ccccc3c2)c(N)n1

InChI Key InChIKey=HRMBCMDDIJSWHA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 585344   

TargetDihydrofolate reductase(Human)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585344(US11530198, Example 19 | 5-(4-(quinolin-3-yl)piper...)
Affinity DataIC50: 129nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Leishmania major)
Vyera Pharmaceuticals

US Patent
LigandPNGBDBM585344(US11530198, Example 19 | 5-(4-(quinolin-3-yl)piper...)
Affinity DataIC50: 3.72nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent