BDBM587314 US11534441, Compound 22::US11534441, Compound 23

SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC[C@H](C)c4n3)ncc12)C(C)(C)N

InChI Key InChIKey=KUNHFCCGDNZLGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 587314   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM587314(US11534441, Compound 22 | US11534441, Compound 23)
Affinity DataIC50: 0.110nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM587314(US11534441, Compound 22 | US11534441, Compound 23)
Affinity DataIC50: 0.5nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent