BDBM587327 US11534441, Compound 35::US11534441, Compound 36

SMILES COc1ncc(c2cc(Nc3ccc4C(=O)OC(C)(C)Cc4n3)ncc12)C(C)(C)N

InChI Key InChIKey=VZNMVZIEWTVUON-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 587327   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM587327(US11534441, Compound 35 | US11534441, Compound 36)
Affinity DataIC50: 0.170nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM587327(US11534441, Compound 35 | US11534441, Compound 36)
Affinity DataIC50: 0.410nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent