BDBM587461 US11534441, Compound 171

SMILES C[C@H]1OC(=O)c2ccc(Nc3cc4c(cnc(OC5CC5)c4cn3)[C@](C)(N)C3CC3)nc2C1(C)C

InChI Key InChIKey=JPKXKHMYTWFNRG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 587461   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM587461(US11534441, Compound 171)
Affinity DataIC50: 0.0700nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent