BDBM587471 US11534441, Compound 181::US11534441, Compound 182

SMILES CC[C@@](C)(N)c1cnc(OCC(F)(F)F)c2cnc(Nc3ccc4C(=O)O[C@@H](C)[C@H](C)c4n3)cc12

InChI Key InChIKey=KENCXGWOJQYCDY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 587471   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM587471(US11534441, Compound 182 | US11534441, Compound 18...)
Affinity DataIC50: 0.180nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM587471(US11534441, Compound 182 | US11534441, Compound 18...)
Affinity DataIC50: 2.92nMAssay Description:Inhibitors were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of each inhibitor was created in 1...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent