BDBM587526 3-((7-cyano-2,4-dioxo- 3-phenethyl-3,4- dihydroquinazolin- 1(2H)-yl)methyl)-N- hydroxybenzamide::US11535598, Compound 7

SMILES ONC(=O)c1cccc(Cn2c3cc(ccc3c(=O)n(CCc3ccccc3)c2=O)C#N)c1

InChI Key InChIKey=UWEGPARKXFKMJU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 587526   

TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587526(US11535598, Compound 7 | 3-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 235nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587526(US11535598, Compound 7 | 3-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 4.45E+3nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587526(US11535598, Compound 7 | 3-((7-cyano-2,4-dioxo- 3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent