BDBM587542 4-((2,4-dioxo-3-(2- (thiophen-2-yl)ethyl)- 3,4-dihydroquinazolin- 1(2H)-yl)methyl)-N- hydroxybenzamide::US11535598, Compound 24

SMILES ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3cccs3)c2=O)cc1

InChI Key InChIKey=VOLJUDGKGGWKBS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 587542   

TargetHistone deacetylase 6(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587542(US11535598, Compound 24 | 4-((2,4-dioxo-3-(2- (thi...)
Affinity DataIC50: 11nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587542(US11535598, Compound 24 | 4-((2,4-dioxo-3-(2- (thi...)
Affinity DataIC50: 287nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587542(US11535598, Compound 24 | 4-((2,4-dioxo-3-(2- (thi...)
Affinity DataIC50: 1.00E+4nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Annji Pharmaceutical

US Patent
LigandPNGBDBM587542(US11535598, Compound 24 | 4-((2,4-dioxo-3-(2- (thi...)
Affinity DataIC50: 1.07E+4nMAssay Description:The IC50 values for aforementioned compounds against HDACs were determined. HDAC 1 to 11 can be assayed by using acetylated AMC-labeled peptide subst...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/20/2023
Entry Details
US Patent