BDBM589068 (E)-1-(10-((3-chloro-4- ((3- fluorobenzyl)oxy)phenyl) amino)-2,3-dihydro-4H- [1,4]oxazino[2,3- f]quinazolin-4-yl)-4- (dimethylamino)but-2- en-1-one::US11548900, Example 45

SMILES CN(C)C\C=C\C(=O)N1CCOc2c1ccc1ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c21

InChI Key InChIKey=ICUWFIDDGKPRGI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 589068   

TargetEpidermal growth factor receptor(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM589068(US11548900, Example 45 | (E)-1-(10-((3-chloro-4- (...)
Affinity DataIC50: 50nMAssay Description:The assay for the inhibition of EGFR and HER2 kinase activity by small molecular compounds was carried out using the method as follows:1) Dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM589068(US11548900, Example 45 | (E)-1-(10-((3-chloro-4- (...)
Affinity DataIC50: 50nMAssay Description:The assay for the inhibition of EGFR and HER2 kinase activity by small molecular compounds was carried out using the method as follows:1) Dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent