BDBM589070 (E)-4-(dimethylamino)- 1-(10-((4-(m- tolyloxy)phenyl)amino)- 2,3-dihydro-4H- [1,4]oxazino[2,3- f]quinazolin-4-yl)but-2- en-1-one::US11548900, Example 47

SMILES CN(C)C\C=C\C(=O)N1CCOc2c1ccc1ncnc(Nc3ccc(Oc4cccc(C)c4)cc3)c21

InChI Key InChIKey=XRPKIDRYIXPEFX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 589070   

TargetEpidermal growth factor receptor(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM589070(US11548900, Example 47 | (E)-4-(dimethylamino)- 1-...)
Affinity DataIC50: 50nMAssay Description:The assay for the inhibition of EGFR and HER2 kinase activity by small molecular compounds was carried out using the method as follows:1) Dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM589070(US11548900, Example 47 | (E)-4-(dimethylamino)- 1-...)
Affinity DataIC50: 50nMAssay Description:The assay for the inhibition of EGFR and HER2 kinase activity by small molecular compounds was carried out using the method as follows:1) Dilution of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent