BDBM592183 US11572344, Compound 1.011::US11572344, Example 11::US20250387379, Compound 1.011

SMILES Cc1cc(I)ccc1Nc1cc(ccc1C(=O)NOCCO)C#N

InChI Key InChIKey=JJVMFDVNVXAYKA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 592183   

TargetMitogen-activated protein kinase kinase kinase 1(Human)
Nflection Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 592183BDBM592183(US11572344, Example 11 | US11572344, Compound 1.01...)
Affinity DataIC50: 825nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Nflection Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 592183BDBM592183(US11572344, Example 11 | US11572344, Compound 1.01...)
Affinity DataIC50: 825nMAssay Description:Reaction buffer: 20mM Hepes (pH 7.5), 10mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02mg/mL BSA, 0.1 mM, Na3VO4, 2mM DTT, 1% DMSO Enzyme: MEK1, Invitrogen c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent