BDBM59228 Pyrazolopyrimidone analog, RGB-285940

SMILES COc1ccc(Cc2nc3n(nc(C(C)C)c3c(=O)[nH]2)-c2c(Cl)cc(Cl)cc2Cl)cc1

InChI Key InChIKey=JNZFKAISGYBGFQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 59228   

LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50: 230nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50: 7nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50: 858nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed
LigandPNGBDBM59228(Pyrazolopyrimidone analog, RGB-285940)
Affinity DataIC50: 410nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2011
Entry Details Article
PubMed