BDBM592405 US11572371, Compound 20

SMILES Cc1nnc2C(Cc3nnc(o3)C3CC3)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1

InChI Key InChIKey=JKLFTZFZNNCDAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 592405   

TargetBromodomain-containing protein 2(Human)
Hinova Pharmaceuticals

US Patent
LigandPNGBDBM592405(US11572371, Compound 20)
Affinity DataIC50: 10.1nMAssay Description:Homogeneous time=resolved fluorescence (HTRF) was used to detect the binding of the compound to BRD4(D1 + D2) and BRDT (D1) proteins, and the AlphaSc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Hinova Pharmaceuticals

US Patent
LigandPNGBDBM592405(US11572371, Compound 20)
Affinity DataIC50: 20nMAssay Description:Homogeneous time=resolved fluorescence (HTRF) was used to detect the binding of the compound to BRD4(D1 + D2) and BRDT (D1) proteins, and the AlphaSc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Hinova Pharmaceuticals

US Patent
LigandPNGBDBM592405(US11572371, Compound 20)
Affinity DataIC50: 25.4nMAssay Description:Homogeneous time=resolved fluorescence (HTRF) was used to detect the binding of the compound to BRD4(D1 + D2) and BRDT (D1) proteins, and the AlphaSc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent

TargetBromodomain testis-specific protein(Human)
Hinova Pharmaceuticals

US Patent
LigandPNGBDBM592405(US11572371, Compound 20)
Affinity DataIC50: 49nMAssay Description:Homogeneous time=resolved fluorescence (HTRF) was used to detect the binding of the compound to BRD4(D1 + D2) and BRDT (D1) proteins, and the AlphaSc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2023
Entry Details
US Patent