BDBM593006 (S)-6-(2,2-difluorocyclopropane-1-carboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide::US11578058, Compound 5::US11578058, Compound 6
SMILES CNC(=O)c1nnc(NC(=O)[C@@H]2CC2(F)F)cc1Nc1cccc(-c2ncn(C)n2)c1OC
InChI Key InChIKey=DFFFANVCCDREBV-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 593006
Affinity DataIC50: 4.90nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:A binding buffer contains 20 mM Hepes pH 7.5, 150 mM NaCl, 10 mM MgCl, 0.015% Brij35, 2 mM DTT, 0.625 mM EGTA and 100 mM KF. The JH2 domain of TYK2 (...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT and 0.01% Brij35 from the kit; a human recombinant ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:A reaction buffer containing the following components: an enzyme buffer (1×), 5 mM MgCl, 1 mM DTT, 10 nM SEB (Cisbio, Cat. No. 61SEBALB), 0.625 mM EG...More data for this Ligand-Target Pair