BDBM595506 US11591318, Example 13

SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#C)(C1)n1cc(c(CO)n1)-c1c[nH]nc1C)C(F)(F)F

InChI Key InChIKey=MKYNOUHWBXPYTQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 595506   

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte

US Patent
LigandPNGBDBM595506(US11591318, Example 13)
Affinity DataIC50: 300nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), JAK2 (a.a. 828-1132) and JAK3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM595506(US11591318, Example 13)
Affinity DataIC50: 1.00E+3nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), JAK2 (a.a. 828-1132) and JAK3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent